Fig. 2.

Impact of Vps34 inactivation on glucose tolerance, insulin sensitivity in lean mice. a Serum glucose levels under randomly fed and fasted conditions. Data represent mean ± SEM (non-parametric Mann–Whitney t-test). b Serum insulin levels under randomly fed and fasted conditions. Data represent mean ± SEM (non-parametric Mann–Whitney t-test). c GTT after intraperitoneal injection of 2 g/kg of glucose in mice after overnight starvation. Data represent mean ± SEM (non-parametric Mann–Whitney t-test). d ITT after intraperitoneal injection of 0.75 U/kg of insulin in mice after overnight starvation. Data represent mean ± SEM (non-parametric Mann–Whitney t-test). For all experiments shown, ≥10 mice/genotype were used. *p < 0.05, **p ≤ 0.01, ***p ≤ 0.001