Figure 2.

In normal wound healing condition, there is a series of ordered process: injury, immune cell recruitment and acute inflammation, myfibroblasts limited activation, and proliferation and ECM homeostasis, leading to wound closure after injury. While in pro-fibrotic condition, pathological process including chronic inflammation, myfibroblasts persistent activation, and proliferation and ECM deposition leading to fibrosis. Fibrosis itself could result in a secondary assault. Extracellular and intracellular factors interact with each other. Their abnormalities contribute to the fibrosis progression and in return are affected by pathological changes. Green lines and blocks represent normal wound healing while red lines and blocks represent fibrosis progression.