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. 2017 Nov 23;8:1432. doi: 10.3389/fimmu.2017.01432

Figure 6.

Figure 6

BKT130Fc and BKT120Fc inhibited the infiltration of inflammatory cells into the synovial cavities of mice of the antigen-induced arthritis (AIA) model. Male C57BL/6 mice (n = 12) were immunized with methylated bovine serum albumin. BKT130Fc or BKT120Fc were administered via i.v. once at 50 µg/per a mouse, 24 h before the challenge. The control group represents normal mice, the AIA group represents untreated AIA mice and the BKT130Fc or BKT120Fc groups represent AIA mice treated with BKT130Fc or BKT120Fc, respectively. The number of infiltrated cells into the knee cavity was evaluated by FACScaliber: (A) number of neutrophils, (B) number of MNCs. Representative FACS analysis of cells within the knee cavity is presented in (D). The R1 gate shows the neutrophil population and the R2 gate shows the MNCs. The level of myeloperoxidase (MPO) activity is presented in (C) as the relative number of neutrophils per mg of wet periarticular tissue. (E) Histology analysis of the knee joint shows the infiltration of inflammatory cells following hematoxylin and eosin (H&E) staining.