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Schematic of the experimental design. The rats were divided into 4 groups: control, Model, Wuji Wan and PB. CM was assessed before beginning the induction of PI-IBS in rats. Wuji Wan or PB was administered by gavage during the second week. Following the third CM test, the rats were decapitated and sacrificed for assays of the gut microbiota and intestinal mucosal ultrastructure.
