Table 2.
Up-regulated proteins of L. casei Zhang-G-1200 compared with its original strain in the presence of the gentamycin.
| Locus | Function | Fold change |
|---|---|---|
| CARBOHYDRATE TRANSPORT AND METABOLISM | ||
| LCAZH_0394 | Hypothetical protein | 2.07 |
| LCAZH_0395 | Mannose-6-phosphate isomerase | 3.06 |
| LCAZH_0403 | PTS system mannose/fructose/N-acetylgalactosamine-specific transporter subunit IIB | 2.23 |
| LCAZH_0503 | Sugar phosphate isomerase/epimerase | 2.19 |
| LCAZH_0604 | PTS system galactitol-specific transporter subunit IIB | 2.1 |
| LCAZH_0605 | PTS system galacitol transporter subunit EIIC | 2.22 |
| LCAZH_1336 | Tagatose-6-phosphate kinase | 2.41 |
| LCAZH_1768 | Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase | 2.13 |
| LCAZH_1771 | PTS system cellobiose-specific transporter subunit IIA | 2.2 |
| LCAZH_1772 | PTS system cellobiose-specific transporter subunit IIB | 2.61 |
| LCAZH_2151 | beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase | 2.14 |
| LCAZH_2624 | PTS system fructose-specific transporter subunit IIB | 2.36 |
| LCAZH_2633 | PTS system galactitol transporter subunit IIB | 2.97 |
| LCAZH_2645 | Hypothetical protein | 2.53 |
| LCAZH_2648 | PTS system galacitol transporter subunit EIIB | 5.79 |
| LCAZH_2649 | PTS system galacitol transporter subunit EIIA | 3.96 |
| LCAZH_2653 | Trehalose-6-phosphate hydrolase | 4.66 |
| LCAZH_2725 | Transaldolase | 4.56 |
| LCAZH_2895 | PTS system mannitol-specific transporter subunit IIBC | 3.96 |
| AMINO ACID TRANSPORT AND METABOLISM | ||
| LCAZH_0084 | Tryptophan synthase subunit alpha | 2.25 |
| LCAZH_0107 | Tetrahydrodipicolinate N-succinyltransferase | 2.25 |
| LCAZH_0201 | Oligopeptide ABC transporter periplasmic protein | 2.04 |
| LCAZH_0418 | Amino acid ABC transporter ATP-binding protein | 2.14 |
| LCAZH_0500 | Amino acid transporter | 2.59 |
| LCAZH_0506 | Shikimate 5-dehydrogenase | 2.08 |
| LCAZH_1596 | Oligopeptide ABC transporter periplasmic protein | 2.47 |
| LCAZH_1682 | Lactoylglutathione lyase-like lyase | 2.22 |
| LCAZH_1886 | Oligopeptide ABC transporter periplasmic protein | 2.92 |
| LCAZH_1980 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase | 2.04 |
| LCAZH_2023 | Dipeptide/oligopeptide/nickel ABC transporter ATPase | 2.21 |
| LCAZH_2024 | Dipeptide/oligopeptide/nickel ABC transporter permease | 2.45 |
| LCAZH_2025 | Dipeptide/oligopeptide/nickel ABC transporter permease | 3.27 |
| LCAZH_2026 | Oligopeptide ABC transporter periplasmic protein | 2.68 |
| LCAZH_2111 | Homoserine dehydrogenase | 2.36 |
| LCAZH_2302 | Aminopeptidase | 6.77 |
| LCAZH_2518 | NADPH-dependent glutamate synthase subunit beta-like oxidoreductase | 3.52 |
| LCAZH_2519 | Glutamate synthase domain 3 | 2.54 |
| LCAZH_2851 | Polar amino acid ABC transporter ATPase | 2.23 |
| ENERGY PRODUCTION AND CONVERSION | ||
| LCAZH_0188 | Acetate kinase | 2.17 |
| LCAZH_1301 | Acetoin/pyruvate dehydrogenase complex, E2 component, dihydrolipoamide succinyltransferase | 2.05 |
| LCAZH_1302 | Acetoin/pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase | 2.13 |
| LCAZH_1396 | Pyruvate-formate lyase | 3.75 |
| LCAZH_2375 | Fumarase | 2.1 |
| NUCLEOTIDE TRANSPORT AND METABOLISM | ||
| LCAZH_1739 | Folate-dependent phosphoribosylglycinamide formyltransferase PurN | 2.5 |
| LCAZH_1740 | Phosphoribosylaminoimidazole (AIR) synthetase | 2.23 |
| LCAZH_1743 | Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain | 2.21 |
| CELL WALL/MEMBRANE/ENVELOPE BIOGENESIS | ||
| LCAZH_0447 | Conjugated bile salt hydrolase-like amidase | 5.04 |
| TRANSCRIPTION | ||
| LCAZH_1410 | GNAT family acetyltransferase | 2.42 |
| LCAZH_2210 | Transcriptional regulator | 3.18 |
| COENZYME TRANSPORT AND METABOLISM | ||
| LCAZH_1463 | Lipoate-protein ligase A | 2.05 |
| TRANSLATION, RIBOSOMAL STRUCTURE AND BIOGENESIS | ||
| LCAZH_1880 | Acetyltransferase | 3.78 |
| POSTTRANSLATIONAL MODIFICATION, PROTEIN TURNOVER, CHAPERONES | ||
| LCAZH_0279 | ADP-ribosylglycohydrolase | 2.51 |
| LCAZH_1344 | Chaperone ClpB | 3.68 |
| LCAZH_1380 | Peptide methionine sulfoxide reductase | 2.23 |
| LCAZH_1398 | Pyruvate-formate lyase-activating enzyme | 2.88 |
| DEFENSE MECHANISMS | ||
| LCAZH_1217 | Multidrug ABC transporter ATPase | 6.01 |
| GENERAL FUNCTION PREDICTION ONLY | ||
| LCAZH_0294 | Alpha/beta hydrolase | 2.64 |
| LCAZH_0305 | NAD(FAD)-dependent dehydrogenase | 2.14 |
| LCAZH_0638 | ABC transporter periplasmic protein | 2.06 |
| LCAZH_0641 | ABC transporter permease | 2.3 |
| LCAZH_0642 | ABC transporter ATPase | 2.15 |
| LCAZH_1865 | Dinucleotide-binding enzyme | 2.05 |
| LCAZH_2372 | Oxidoreductase | 2.53 |
| LCAZH_2373 | Short-chain alcohol dehydrogenase | 3.71 |
| FUNCTION UNKNOWN | ||
| LCAZH_0227 | Alkaline shock protein | 21.93 |
| LCAZH_2030 | Hypothetical protein | 3.57 |
| LCAZH_2301 | Putative integral membrane protein | 3.32 |
| LCAZH_2056 | Hypothetical protein | 2.3 |
| LCAZH_2222 | Hypothetical protein | 3.29 |
| LCAZH_1464 | Hypothetical protein | 3.26 |
| LCAZH_1898 | Hypothetical protein | 2.42 |
| LCAZH_0186 | Hypothetical protein | 2.34 |