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. 2017 Nov 27;7:16360. doi: 10.1038/s41598-017-16611-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enhancer profiling of LIF-independent iOCT4 ES cells (A) Boxplot and (B) scatter plots of H3K27ac densities (log2 normalized tag density; RPBM) at ESC-peaks in control ES cells, LIF-independent iOCT4 ES cells, EpiSCs, and MEFs. (C) Boxplot H3K27ac density at ESC super-enhancers. (D) Venn diagrams showing overlap between H3K27ac and ESC super-enhancers in control ES cells, LIF-independent iOCT4 ES cells, EpiSCs, and MEFs. (E) Boxplot and (F) scatter plots of H3K4me2 densities at ESC-peaks. (G) Boxplot of H3K4me2 density at ESC super-enhancers. (H) Principal component analysis (PCA) of H3K27ac and H3K4me2 levels between LIF-independent iOCT4 ES cells, wild-type ES cells, EpiSCs, and MEFs. (I) Browser view of H3K27ac and H3K4me2 in control ES cells, LIF-independent iOCT4 ES cells, EpiSCs, and MEFs.