Table 2.
Univariate and multivariate analysis of overall survival
| Variables |
Univariate analysis |
Multivariate analysis |
||||
| HR | 95%CI | P value | HR | 95%CI | P value | |
| Age | 0.989 | 0.970-1.009 | 0.271 | - | - | - |
| Sex | 0.489 | 0.293-0.815 | 0.006 | 0.346 | 0.154-0.776 | 0.010 |
| Smoke status | 0.745 | 0.595-0.932 | 0.010 | 1.071 | 0.761-1.507 | 0.694 |
| Alcohol intake | 0.817 | 0.546-1.223 | 0.327 | - | - | - |
| G grade | 1.131 | 0.836-1.530 | 0.533 | - | - | - |
| TNM stage | 2.001 | 1.564-2.560 | < 0.001 | 1.755 | 1.288-2.390 | < 0.001 |
| CHI3L1 | 1.002 | 1.001-1.004 | 0.011 | 1.004 | 1.002-1.005 | < 0.001 |
| SCCA | 1.065 | 1.028-1.104 | < 0.001 | 1.056 | 1.013-1.100 | 0.010 |
| CEA | 1.048 | 0.972-1.130 | 0.224 | - | - | - |
| Treatment | 1.402 | 1.218-1.613 | < 0.001 | 1.167 | 0.979-1.391 | 0.084 |
Variables: Age, ≥ 60 vs < 60; gender, female vs male; smoke, smoker vs non-smoker; alcohol intake, yes vs no; grade, grade 3 vs grade 2 vs grade 1; stage, IV vs III vs II vs treatment, surgery vs chemotherapy vs chemoradiotherapy; -: Represent “date not available”. CHI3L1: Chitinase 3-like 1; SCCA: Squamous cell carcinoma antigen; CEA: Carcinoembryonic antigen.