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. 2017 Nov 27;7:16356. doi: 10.1038/s41598-017-16690-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental Design. Rats in Experiment 1 (n = 5) underwent intranigral administration of viral vector and were assessed using the cylinder task at 16 and 55 days after surgery. Rats in Experiment 2 (n = 12) underwent the same viral vector surgery and cylinder testing at Day 16 as in Experiment 1, but on Day 18 were implanted with an electrode in the STN. Rats were randomly assigned to receive continuous stimulation through Day 54 (‘Active’, n = 6) or to not have the electrode activated (‘Inactive’, n = 6). On Day 54, the cylinder task was conducted, and afterward, stimulation was ceased for 24 hours for forelimb asymmetry examination in the stimulation ‘off’ state at Day 55. After the cylinder task was completed on Day 55, stimulation was restarted for Active rats and continued until sacrifice. All rats in Experiments 1 and 2 were sacrificed on Day 56.