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. 2017 Nov 27;7:16356. doi: 10.1038/s41598-017-16690-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of α-syn Overexpression on Total and Phosphorylated Levels of rpS6. Representative, low- and high-magnification images (A–D and E–H, respectively) from the SNpc ipsilateral to rAAV2/5 α-syn injection displaying triple label immunofluorescence for tyrosine hydroxylase (TH, green, A,E), ribosomal protein S6 (rpS6, red, B,F) and human alpha-synuclein (α-syn, blue, C,G). Merged images showing numerous SNpc neurons co-expressing all three proteins are shown at low (D) and high (H) magnification. From the same rat in an adjacent section, the ipsilateral SN is shown at low and high magnification for TH (L,P), p-rpS6 (M,Q), human α-syn (N,R) and merged images (O,S). Quantification of the No Electrode group (n = 5) was assessed between hemispheres to determine the effect of α-syn overexpression on TH (I), rpS6 (J) and p-rpS6 (K). A difference between hemispheres was observed for TH (I, p = 0.003) and p-rpS6 (K, p = 0.004). Scale bars are 200 μm and 50 μm for low- and high-magnification images, respectively.