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. 2017 Nov 27;7:16356. doi: 10.1038/s41598-017-16690-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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STN Stimulation Does Not Alter Symptom Progression Nor Neuropathology. Both Inactive and Active groups (n = 6 per group) exhibited forepaw use asymmetry after eight weeks compared to baseline or just prior to electrode placement surgery (A, p = 0.004 and p = 0.011, respectively); though, there was no interaction between group and time, so stimulation did not significantly alter the development of symptoms at eight weeks. THir SNpc neurons were not different between Active (shown in B at low magnification and in C and D at high magnification for the ipsilateral and contralateral SNpc, respectively) and Inactive groups (E, p = 0.314). (F) Striatal THir was not significantly different between groups (p > 0.05) but was significantly different between hemispheres for Inactive (p = 0.0002) and Active groups (p = 0.0087). Inspection of the α-syn-ir or THir striatum (G,H and I,J, respectively, for low and high magnification photomicrographs of an Active rat) did not reveal any apparent differences to a blinded investigator in α-syn-ir aggregates (G,H) or THir axonal swellings (I,J) between Active and Inactive rats. Scale bars are 50 μm.