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. 2017 Nov 27;7:16356. doi: 10.1038/s41598-017-16690-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of STN DBS on Phosphorylated and Total Levels of rpS6. Quantification of the Inactive and Active groups was assessed between hemispheres and treatments to determine the effect of stimulation on p-rpS6 (A) and rpS6 (B). (A) THir SN neurons expressing hu-α-syn exhibited significantly more p-rpS6 immunoreactivity (Inactive, n = 6: t₍₅₎ = 2.805, p = 0.0378; Active, n = 6: t₍₅₎ = 3.040, p = 0.0287). However, p-rpS6 appeared to increase slightly within α-syn expressing THir SN neurons in association with stimulation, whereas STN DBS overall had no significant impact on p-rpS6 immunoreactivity in either the ipsilateral or contralateral SNpc (F_(3,22) = 5.715, p > 0.05). (B) Total rpS6 was significantly increased in THir SN neurons expressing hu-α-syn in Inactive rats (n = 4; p = 0.0491) but not in Active Rats (n = 6; p > 0.05). Active STN DBS did not affect rpS6 immunoreactivity in hu-α-syn expressing neurons (p > 0.05) but did increase rpS6 immunoreactivity in the contralateral SNpc THir neurons (p = 0.004).