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. 2017 Nov 27;7:16398. doi: 10.1038/s41598-017-16300-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Islet size distribution, cellular composition. (A) Quantitative analysis of individual islet size distribution and cellular composition. Relative frequency of islet size (gray bar) and ratios of beta (green), alpha (red), and delta (blue) cells within islets are plotted against islet size; means ± SEM. Note that islet size is presented as a logarithmic scale considering the high number of small islets and the low number of large islets. In addition, islet area is divided by the single-cell area (178 μm²)²⁰ to make them as dimensionless values representing the number of cells in a given islet area. See the conversion between logarithmic islet area (logarithmic) and effective diameter (μm). (B) 3D visualization of islet size and shape distribution. Each dot represents a single islet/cluster with reference to size (area) and shape. Circularity reports the degree of roundness of a structure, where 1.0 corresponds to a perfect circle. Feret’s diameter is the longest distance within a structure. Circularity and Feret’s diameter are closely related that together depict a shape of a given structure. The density of islets is color-coded from sparse to dense.