Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 27;7:16386. doi: 10.1038/s41598-017-15575-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Unconventional MTs carrying 14-pfs in rat femoral nerves. Rat femoral nerves with or without ligation were embedded into resin block and examined by TEM. (a) Overview of a micrograph with conventional MTs carrying 13-pfs. The rectangle surrounded area was enlarged and shown in (d). (b) Overview of a micrograph showing unconventional MTs containing 14-pfs. The rectangle surrounded area was enlarged and shown in (e). (c) Overview image of the ligated femoral nerve. Unconventional MTs were captured in ligated nerve, and the rectangle surrounded area was enlarged and shown in (f). (g) Comparison of unconventional MTs in unligated and ligated femoral nerves. The percentage of MTs with 14-pfs in the unligated femoral nerve is 0.5% (10 of 2016 MTs), in the ligated nerve is 8.8% (22 of 230 MTs). (h) Localization of αSyn in femoral nerves visualized by IEM. Silver-enhanced gold particles are observed surrounding fuzzy material around MTs with 14-pfs (right panel), but are not visible in MTs with 13-pfs (left panel). (i) Model for the tMT in the anterograde transport of cytoplasmic dynein by kinesin-1. LIS1 anchors cytoplasmic dynein to a Syn-stabilized tMT followed by the tethering to a kinesin molecule under mNudC mediation. Scale bar: 50 nm in (a–c); and 25 nm in (h).