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. 2017 Nov 27;7:16364. doi: 10.1038/s41598-017-16571-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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C-T-P network. The link is placed between a target and a compound of the 10 different drug combinations if the compound is lighted at the target. The link is placed between a target and a pathway if the pathway is lighted at the target. The information of pathways is obtained by mapping the target proteins to the KEGG pathway database. The letters are node labels.