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. 2017 Nov 27;7:16374. doi: 10.1038/s41598-017-12562-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Baicalein inhibited NF-κB pathway in TNBS-induced mice. (A) Colon segments from mice were excised and homogenized. The supernatants were assayed for the determination of the activity of MPO. (B) mRNA expression of iNOS, ICAM-1, MCP-1, COX-2, TNF-α, and IL-1β in colonic tissue was determined by qRT-PCR. Expression was normalized to β-actin. (C) Representative images of p-p65 immunostaining in colonic tissue. Scale bar corresponds to 50 μm and applies throughout. (D) The mean intensity of p-p65 staining was determined by image analysis and was represented as optical density. Data were expressed as mean ± SD (n = 6). ^###p < 0.001 vs. vehicle-treated group; *P < 0.05, **p < 0.01, ***P < 0.001 vs. TNBS-treated group.