Table 6.
Modular response analysis (MRA) results
| Regulation of STAT3 by | ||||
| Dataset | Akt | Erk | p38 | JNK |
| HME | ||||
| BVSA-cell | N/I | −0.887 ± 0.139 | −0.802 ± 0.174 | N/I |
| BVSA-both | 0.049 ± 0.106 | −0.872 ± 0.139 | −0.778 ± 0.180 | N/I |
| MRA-0 | 0.260 ± 0.136 | −0.579 ± 0.174 | −0.715 ± 0.145 | 0.408 ± 0.158 |
| MRA-1 | N/I | -0.796 ± 0.174 | −0.811 ± 0.169 | 0.156 ± 0.161 |
| MRA-2 | N/I | -0.887 ± 0.139 | −0.802 ± 0.174 | N/I |
| MDA-MB-231 | ||||
| BVSA-cell | 0.600 ± 0.074 | N/I | N/I | N/I |
| BVSA-both | 0.487 ± 0.127 | 0.360 ± 0.458 | 0.004 ± 0.392 | N/I |
| MRA-0 (90.8 vs 9.2%)a |
0.767 ± 0.333 | −1.305 ± 0.464 1.634 ± 0.483 |
−0.210 ± 0.372 | 2.954 ± 0.771 −2.623 ± 0.848 |
| MRA-1 (90.2 vs 9.8%)a |
0.760 ± 0.354 | −1.651 ± 0.543 2.176 ± 0.545 |
N/I | 3.170 ± 0.853 −2.994 ± 0.898 |
| MRA-2 (17.7 vs 82.3%)a |
N/I | −1.985 ± 0.547 2.288 ± 0.420 |
N/I | 3.753 ± 0.846 −3.212 ± 0.689 |
| MRA-3 | 0.600 ± 0.074 | N/I | N/I | N/I |
Notation used in this table is the same as in Table 2
aAs discussed in the main text, estimated interaction strengths for STAT3 ← Erk and STAT3 ← JNK interactions had bimodal distributions in some of the analyzed cases. These values report the percentage of the runs that resulted in the indicated modes, respectively