Table 7.
Motility of MDA-MB-231 breast cancer and human mammary epithelial cells
| Inhibitor treatment | Normal | Cancer | ||
|---|---|---|---|---|
| vins (μm/min) | RMSD (μm) | vins (μm/min) | RMSD (μm) | |
| No inhibitor | 0.086 ± 0.038 | 3.99 ± 4.72 | 0.228 ± 0.155 | 8.25 ± 9.98 |
| Erk | 0.100 ± 0.050 | 4.31 ± 4.99 | 0.119 ± 0.113 | 5.80 ± 8.75 |
| p38 | 0.089 ± 0.043 | 3.82 ± 4.53 | 0.197 ± 0.155 | 8.67 ± 11.43 |
| JNK | 0.187 ± 0.093 | 11.76 ± 12.95 | 0.216 ± 0.126 | 10.16 ± 12.85 |
| Akt | 0.134 ± 0.057 | 8.74 ± 9.61 | 0.205 ± 0.135 | 8.52 ± 11.92 |
| STAT3 | 0.057 ± 0.051 | 2.15 ± 3.52 | 0.105 ± 0.097 | 4.40 ± 6.94 |
| STAT3 + p38 | 0.051 ± 0.071 | 1.72 ± 3.20 | 0.123 ± 0.131 | 4.11 ± 6.70 |
| STAT3 + JNK | 0.046 ± 0.035 | 1.79 ± 2.28 | 0.115 ± 0.109 | 3.66 ± 5.98 |
| p38 + JNK | 0.080 ± 0.061 | 3.61 ± 5.07 | 0.200 ± 0.161 | 7.50 ± 10.01 |
| Erk + p38 | 0.087 ± 0.099 | 2.78 ± 5.07 | 0.103 ± 0.094 | 4.63 ± 6.36 |
| Erk + JNK | 0.087 ± 0.069 | 4.56 ± 6.26 | 0.129 ± 0.125 | 5.10 ± 7.16 |
| Erk + Akt | 0.098 ± 0.110 | 4.55 ± 5.05 | 0.093 ± 0.081 | 3.55 ± 5.26 |
How vins and RMSD were computed is explained in the Methods section. They were computed for each cell individually and then averaged over the cells to obtain the tabulated values. Cases that show significant differences from the no inhibitor control case are highlighted in bold. Plain bold marks significantly different than control where motility decreased upon inhibition. Italicized bold marks significantly different from control where motility increased upon inhibition