Table 2.
Association between genotypes of index malaria resistance polymorphisms or their proxies with Burkitt Lymphoma, stratified by age group.
| Gene | SNP | Genotype | < 9 years |
9–15 years |
p-Value for heterogeneity |
|---|---|---|---|---|---|
| Adjusted OR (95% CI)c | Adjusted OR (95% CI)c | ||||
| IL10 | rs1800896a | IL10b | |||
| TT | Ref. | Ref. | |||
| CT | 0·87 (0·54–1·41) | 0·55 (0·29–1·05) | |||
| CC | 0·40 (0·18–0·91) | 0·66 (0·26–1·64) | |||
| p = 0·064 | p = 0·191 | p = 0·445 | |||
| IL10 | rs3024500a | IL10 | |||
| AA | Ref. | Ref. | |||
| AG | 0·93 (0·57–1·51) | 0·80 (0·40–1·60) | |||
| GG | 0·47 (0·23–0·99) | 0·742 (0·32–1·17) | |||
| p = 0·096 | p = 0·756 | p = 0·465 | |||
| IL1A | rs2856838 | IL1A | |||
| GG | Ref. | Ref. | |||
| AG | 0·67 (0·42–1·07) | 0·48 (0·25–0·900) | |||
| AA | 0·51 (0·19–1·36) | 0·60 (0·20–1·82) | |||
| p = 0·143 | p = 0·066 | p = 0·697 | |||
| CD36 | rs3211938a | CD36 | |||
| TT | Ref. | Ref. | |||
| GG/GT | 1·43 (0·68–2·98) | 2·51 (1·05–6·041) | |||
| p = 0·354 | p = 0·040 | p = 0·197 | |||
| SEMA3C | rs17154508 | SEMA3C | |||
| CT/TT | Ref. | Ref. | |||
| CC | 0·89 (0·56–1·42) | 0·57 (0·31–1·070) | |||
| p = 0·628 | p = 0·075 | p = 0·284 | |||
| SEMA3C | rs4461841 | SEMA3C | |||
| TT | Ref. | Ref. | |||
| CC/CT | 0·61 (0·33–1·15) | 0·49 (0·21–1·16) | |||
| p = 0·115 | p = 0·092 | p = 0·567 | |||
| HBB | rs1609812 | HBB | |||
| AA | Ref. | Ref. | |||
| AG/GG | 1·57 (0·90–2·73) | 1·30 (0·59–2·85) | |||
| p = 0·116 | p = 0·514 | p = 0·587 | |||
| HBB | rs334a | HBB | |||
| AA | Ref. | Ref. | |||
| AT | 0·39 (0·18–0·84) | 0·36 (0·15–0·89) | |||
| p = 0·010 | p = 0·019 | p = 0·930 | |||
| IFNAR1 | rs1041429 | IFNAR1 | |||
| GG | Ref. | Ref.) | |||
| AG | 0·92 (0·43–1·49) | 0·76 (0·40–1·42) | |||
| AA | 0·48 (0·22–1·04) | 0·72 (0·25–2·06) | |||
| p = 0·141 | p = 0·640 | p = 0·477 | |||
| IFNAR1 | rs914142 | IFNAR1 | |||
| AG/GG | Ref. | Ref. | |||
| AA | 1·99 (1·21–3·28) | 0·75 (0·40–1·39) | |||
| p = 0·007 | p = 0·356 | p = 0·015 |
a
Index SNP, otherwise proxy SNP.
b
SNP genotypes were coded using an additive genetic model that counts the number of minor alleles. Genotypes for uncommon alleles were coded by combining the minor homozygotes and heterozygotes in one group.
c
Adjusted for gender, age group, current malaria infection (see text in methods), region, inpatient and outpatient malaria treatment (base model). Individuals with missing data for the exposure variable of interest were excluded from the model when estimating the association.