Table 3. . Associations between maternal gestational weight gain and mean DNA methylation, adjusted for ethnic origin and age at blood draw (β [95% CI]; shaded = p < 0.01).
| GWG | Per kg | Per quartile | Quartile 2 (vs lowest) | Quartile 3 (vs lowest) | Quartile 4 (vs lowest) | F-test for Δ (p-value) |
|---|---|---|---|---|---|---|
| ABCA1 | -0.2 [-0.4, -0.01] |
-1.0 [-1.8, -0.3] |
-0.2 [-3.3, 2.9] |
-1.1 [-3.3, 1.1] |
-3.2 [-5.5, -0.9] |
0.032 |
| HSD11B2 | -0.008 [-0.05, 0.03] |
0.03 [-0.2, 0.2] |
-0.4 [-1.0, 0.2] |
-0.07 [-0.7, 0.5] |
-0.01 [-0.6, 0.6] |
0.356 |
| INS-IGF2 | -0.01 [-0.1, 0.1] |
0.1 [-0.3, 0.6] |
0.6 [-1.0, 2.2] |
0.8 [-0.5, 2.2] |
0.4 [-1.2, 1.9] |
0.646 |
| LEP | 0.05 [-0.3, 0.4] |
0.3 [-0.9, 1.5] |
-1.8 [-5.6, 1.9] |
0.6 [-3.0, 4.3] |
0.2 [-3.5, 3.8] |
0.614 |
| NR3C1 | -0.01 [-0.1, 0.1] |
-0.2 [-0.8, 0.3] |
-0.8 [-2.5, 1.0] |
-0.6 [-2.1, 0.9] |
-0.8 [-2.6, 1.1] |
0.411 |
GWG: Gestational weight gain.