Table 1.

Group A: Symptom profiles of patients with ≥4 medically unexplained symptoms and total adverse childhood experiences (ACE) scores.

Patient (n = 17)	Age (Years)	Sex	Medically-Unexplained Symptoms						Other Medical Problems	Duration of Medical Symptoms	Total ACE Score
			Executive Dysfunction	Sleep Problems	Autonomic Symptoms	Emotional Dysregulation	Digestive/Urinary Problems	Somatization
1	14	F	Attention problems	Insomnia	None	Anxiety, panic attacks	Constipation, frequent urination	Tremor, weakness	Asthma, chronic fatigue	6 years	3
2	8	F	Poor memory and attention	Nightmares	Dizziness	Cries easily, temper tantrums	None	Headache, blurred vision		4-months	3
3	14	M	Poor attention	Insomnia	Dizziness, syncope	Anxiety, depression, self-harm, suicidality	Diarrhea	Headache weakness, paresthesias	Sinus bradycardia, chronic fatigue	8-months	2
4	15	F	Poor memory and attention	Insomnia, frequent night wakings	Dizziness, syncope,	Anxiety, depression, panic attacks	Constipation	Headache, weakness, paresthesias, abdominal pain	Asthma, cardiac rhythm disturbance, chronic fatigue	4-months	2
5	15	F	Poor concentration	Insomnia	Dizziness	Anxiety, OCD, depression, panic attacks	Reflux, diarrhea	Headache, paresthesias, abdominal pain	Asthma	18-months	1
6	7	M	Poor attention	Insomnia, frequent night wakings	Dizziness	Anxiety, fearfulness	Constipation, nocturnal enuresis	Headaches, blurred vision, paresthesias, weakness	Chronic fatigue	3-years	4
7	13	F	Poor memory and attention	Insomnia, frequent night wakings	Dizziness	Anxiety, depression, panic attacks, self-harm, suicidality	None	Headaches, blurred vision, PNES	Eating disorder, chronic fatigue	4-years	5
8	13	F	Poor attention	Insomnia, nightmares	Migraine	Anxiety, depression, rage and panic attacks	Constipation, vomiting, frequent urination	Abdominal pain	Asthma, tics	8-years	0*
9	5	M	Poor attention	Frequent night wakings, nightmares	None	Anxiety, fear, temper tantrums	Diarrhea, nocturnal enuresis	Headaches, abdominal pain	Asthma, chronic fatigue	2-years	6
10	17	F	Poor memory and attention	Insomnia, night sweats	Dizziness, syncope	Anxiety, depression, anorexia, self-harm	Diarrhea, constipation	Headaches, weakness, PNES	Eating disorder, POTS, sleep apnea, chronic fatigue	3-years	3
11	5	M	Poor memory and attention	Insomnia, frequent night wakings	None	Anxiety, fear, OCD, separation anxiety	None	Headaches	Sleep apnea, tics	3-years	4
12	17	F	Poor memory, slow processing	Insomnia	Dizziness	Anxiety, depression, panic attacks	None	Headaches, blurred vision, unsteady gait, chest pain, tinnitus	Frequent ear infections, chronic fatigue	2-years	2
13	15	F	Poor memory, slow processing	Insomnia	Dizziness	Anxiety, depression, panic attacks	Diarrhea, constipation	Headaches, numbness, pelvic pain	Asthma, chronic fatigue	1-year	0*
14	15	F	Poor memory	Insomnia, frequent night wakings	Dizziness, syncope	Anxiety, depression	Nausea	Headaches, numbness, neck pain, unsteady gait	POTS, chronic fatigue	18-months	2
15	13	M	Poor attention	Insomnia	Dizziness	Panic attacks, rage attacks	Nausea, reflux	Headaches, blurred vision, paresthesias	Derealization, depersonalization,	10-months	4
16	16	F	None	Insomnia, nightmares	Dizziness, migraine	Anxiety, depression, panic and rage attacks, suicidality	Diarrhea, dysuria	Neck pain, back pain	Asthma, eating disorder, heart palpitations, chronic fatigue	5-years	5
17	10	F	Poor attention	Insomnia, nightmares	None	Rage attacks, panic attacks	None	Headaches, abdominal pain, blurred vision	Heart palpitations, shortness of breath, tics	5-years	5

Abbreviations: F = Female, M = Male, PNES—psychogenic non-epileptic events, POTS—Postural orthostatic tachycardia syndrome, OCD—obsessive compulsive disorder. * Other adverse childhood experience, not included the ACE score (homeless, foster care, near-drowning accident).