Figure 2.

The current active approaches to overcome resistance to ALK inhibitors. The most common approach mainly relies on second and third generation ALK inhibitors such as ceritinib, alectinib, and brigatinib. The less common approach relies on re-sensitizing resistant cells to ALK inhibitors by targeting other signaling pathways. X represents the inhibitory effect of the ALK inhibitor. Green triangle represents the addition of another ALK inhibitor. PI3K: Phosphoinositide 3-kinase; HSP90: heat shock protein 90.