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. 2017 Oct 30;9(11):149. doi: 10.3390/cancers9110149

Figure 2.

Figure 2

Inhibition profiling of ALK-Y1278S with ALK inhibitors. (A) PC12 cells expressing ALK-Y1278S were treated with serial dilutions of ALK inhibitors as indicated. Phosphorylation of ALK was detected with anti-pALK (Y1604) antibody and total ALK was used as internal control. Data were normalized to non-treated controls as percentage of pALK intensity. Inhibition curves were generated with GraphPad Prism 7.02. Half maximal inhibitory concentrations (IC50s) of different ALK inhibitors are shown in (B) as mean ± STD from three independent experiments. * Data cited from [26]. ** Data from [25]. *** Data from [24].