Table 1.
Main genes and genomic alterations which can be detected in late stage NSCLC using tissue and/or liquid biopsies. +: worse approach; ++: intermediate option; +++: best approach.
| Gene/Genomic Alteration | Detection by Liquid Biopsy [Ref] | Detection by Tissue Biopsy [Ref] |
|---|---|---|
| EGFR/mutations | +++ [6,7,8,9,10,11,12,13,14,15,16,17] |
+++ [7,10,17,18] |
| ALK/rearrangement | + [19,20,21,22,23,24] |
+++ [22,25] |
| ROS1/rearrangement | + [26,27] |
+++ [27] |
| NTRK/rearrangement | + [28] |
+++ [29] |
| RET/rearrangement or mutations | + [30] |
+++ [31] |
| BRAF/mutations | +++ [32] |
+++ [33] |
| HER2/mutations or amplification | ++ [17] |
+++ [34,35] |
| MET/mutations or amplification or expression | ++ [17,36] |
+++ [36,37] |