Table 3.

Aptamers for lung cancer diagnostics and therapy.

Aptamers	Target Cells	Protein Target	Application	Reference
Small cell lung cancer
HCA12 HCC03 HCH07 HCH01	Cell lines: NCI–H69 NCI–H146 NCI–H128	Not determined	Formalin-fixed, Paraffin-embedded Tissue Array; Extraction and Detection with Aptamer Conjugated Magnetic/Fluorescent Nanoparticles using fluorescence microscopy and flow cytometry	[108]
16-1	SBC3 cell line	Not determined	Fluorescence microscopy and flow cytometry	[109]
Lung Adenocarcinoma
EJ7 ADE2	H23 cell line H23, A549 cell line	Not determined	Flow cytometry	[110]
S13, S50	EGFR-transfected A549 cell line	EGFR	Antiproliferative activity	[111]
R50	A549 cells transfected with EGFR-GFP	NCL	Apoptosis induction	[112]
LC-17	Post-operative tissue	TUB	Aptahistochemical analyses of tissues Isolation of circulating tumor cells	[62,88]
LC-18,	Post-operative tissue	VIM, LMN	Aptahistochemical analyses of tissues Isolation of circulating tumor cells Electrochemical detection of protein biomarkers in human blood plasma	[62,88,103]
LC-224	Post-operative tissue	ACT methylated at position 73	Aptahistochemical analyses of tissues	[88]
LC-110	Post-operative tissue	CLU H2B	Isolation of circulating tumor cells	[62]
LC-183	Post-operative tissue	CTSD	Isolation of circulating tumor cells Inhibition of growth of primary cancer cell cultures	[62,113]
MA3	Сell lines: A549, MCF-7	MUC1	Targeted delivery of doxorubicin	[114]
MUC-1 aptamer	A549 cell line	MUC1	Targeted delivery of plasmid DNA	[115]
GL21.T	A549 (Axl+) cell line	AXL	Aptamer used as carriers for cell-targeted delivery of a miRNA with tumor suppressor function, let-7g; miR-212	[116,117],
Other
aptNCL	CL1-5 cell line	NC L	Targeted delivery of siRNA chimeras	[118]
AS1411	Multiple cancer cell types	NC L	PET imaging of lung cancer with Cu-64 labeled aptamer	[119]
S1, S6, S11e, S15	NSLC	Not determined		[120]