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. 2017 Nov 24;49(11):e399. doi: 10.1038/emm.2017.184

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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SGK1 promotes colonic tumor cell proliferation and migration and inhibits 5-FU-induced cell apoptosis. (a) EdU assay of HCT116 cells upon treatment with SGK1 overexpression plasmids (SGK1) and SGK1 inhibitor (GSK650394); scale bars, 200 μm; n=4. (b) Cell cycle analysis of HCT116 cells by flow cytometry; n=4. (c) EdU staining of HT29 cells; scale bars, 200 μm; n=4. (d) Cell cycle analysis of HT29 cells; n=3. (e) Cell apoptosis analysis of HCT116 cells; n=4. (f) Transwell analysis of HCT116 cell migration; scale bars, 100 μm; n=4; ***P<0.001.