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. 2017 Nov 24;49(11):e399. doi: 10.1038/emm.2017.184

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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SGK1 regulates p27 mRNA and protein levels. (a) p27 mRNA levels in HCT116 cells treated with SGK1 overexpression plasmids or the SGK1 inhibitor GSK650394. (b) p27 and SGK1 protein expression levels. (c–e) HCT116 cells treated with GSK650394 (10 μM), MG132 (10 μM) or GSK650394 (10 μM)+MG132 (10 μM) for 24 h were subjected to western blot analysis to detect p27 in total cell lysates (c), the cytoplasmic fraction (d) and the nuclear fraction (e). *, 0.01<P<0.05; **, 0.001<P<0.01; ***P<0.001.