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. 2017 Nov 24;49(11):e399. doi: 10.1038/emm.2017.184

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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SGK1 shRNA upregulates p27 expression and attenuates tumor growth and cellular proliferation in the subcutaneous xenograft mouse model. (a) Establishment of the lentivirus-based SGK1 shRNA stable HCT116 cell line. (b) Establishment of the xenotransplant mouse model; n=4. (c) p27 expression in xenograft tumor samples. (d, e) Transplanted tumor volume and size; n=4. (f) Ki67- and PCNA-positive cell populations in xenograft tumor tissues. Scale bars, 200 μm; *P<0.05; **P<0.01; ***P<0.001.