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Therapeutic SGK1 inhibition upregulates p27 expression and represses tumor growth and cellular proliferation in the subcutaneous xenograft mice model. (a) The procedure of establishing a xenotransplant mouse model, followed by treatment with GSK650394; n=8. (b) p27 expression in xenograft tumor samples. (c, d) Transplanted tumor volume and size; n=8. (e) Ki67- and PCNA-positive cell populations in xenograft tumor tissues. Scale bars, 200 μm; *P<0.05; ***P<0.001.
