Figure 4.

Pathway enrichment analysis of compound targets, uterine fibroids targets and compound targets/uterine fibroids targets. According to pathway enrichment analysis, compound targets of GFW and uterine fibroids targets were related to various pathways. Green diamonds and pink, orange and blue circles represent the herbs, compound targets, uterine fibroids targets and compound-uterine fibroids targets, respectively; Red squares indicate the pathway; red lines indicate the associations between pathways and targets; green lines indicate the associations between herbs and targets; orange lines indicate the associations between uterine fibroids targets and other nodes; and blue lines indicate the associations between compound-uterine fibroids targets and other nodes. PI3K, phosphoinositide 3-kinase; Akt, protein kinase B; Erk, extracellular signal-regulated kinase; NF-κB, nuclear factor-κB; TGF-β, transforming growth factor-β; IGF, insulin-like growth factor; EGF, epidermal growth factor; Wnt, wingless-type; VEGF, vascular endothelial growth factor; mTOR, mechanistic target of rapamycin; MAPK, mitogen-activated protein kinase; PDGF, platelet-derived growth factor; C.R., Cinnamomi Ramulus; C.M., Cortex Moutan; P.S., Persicae Semen; P.C.W., Poria Cocos(Schw.) Wolf.; R.P.R., Radix Paeoniae Rubra.