Table I.
GO enrichment analysis of compound targets, uterine fibroids targets and compound targets/uterine fibroids targets.
| GO ID | Pathway | Gene count | % | P-value | Fold enrichment | Benjamini |
|---|---|---|---|---|---|---|
| 0043401 | Steroid hormone mediated signaling | 26 | 0.040 | 4.80E-24 | 16.1 | 5.60E-21 |
| 0032355 | Response to estradiol | 24 | 0.037 | 9.40E-14 | 7.5 | 2.50E-11 |
| 0043627 | Response to estrogen | 15 | 0.023 | 1.70E-9 | 8.4 | 1.40E-7 |
| 0032570 | Response to progesterone | 7 | 0.011 | 6.90E-4 | 6.4 | 1.30E-2 |
| 0048010 | Vascular endothelial growth factor receptor signaling | 41 | 0.063 | 5.80E-18 | 5.3 | 3.40E-15 |
| 0007173 | Epidermal growth factor receptor signaling | 38 | 0.058 | 1.40E-13 | 4.3 | 3.40E-11 |
| 0008543 | Fibroblast growth factor receptor signaling | 35 | 0.054 | 8.70E-13 | 4.4 | 1.90E-10 |
| 0048009 | Insulin-like growth factor receptor signaling | 4 | 0.006 | 5.80E-3 | 10.4 | 8.10E-2 |
| 0008285 | Negative regulation of cell proliferation | 34 | 0.052 | 1.40E-8 | 3.1 | 9.30E-7 |
| 0048662 | Negative regulation of smooth muscle cell proliferation | 8 | 0.012 | 2.50E-5 | 8.9 | 7.50E-4 |
| 0048384 | Retinoic acid receptor signaling | 7 | 0.011 | 3.80E-6 | 15.1 | 1.40E-4 |
| 0033189 | Response to vitamin A | 7 | 0.011 | 7.90E-6 | 13.5 | 2.70E-4 |
| 0032526 | Response to retinoic acid | 8 | 0.012 | 2.60E-4 | 6.2 | 5.70E-3 |
| 0007179 | Transforming growth factor-β receptor signaling | 15 | 0.023 | 1.90E-5 | 4.1 | 6.10E-4 |
| 0030512 | Negative regulation of transforming growth factor-β receptor signaling | 9 | 0.014 | 9.70E-4 | 4.4 | 1.80E-2 |
| 0043065 | Positive regulation of apoptotic processes | 23 | 0.035 | 2.50E-5 | 2.8 | 7.60E-4 |
| 0006915 | Apoptotic processes | 33 | 0.051 | 2.30E-4 | 2.0 | 5.00E-3 |
Benjamini score was derived from the DAVID database. Percentage values were calculated from the associated genes/total genes. GO, gene ontology.