Table IV.
Pathway enrichment analysis of compound targets, uterine fibroids targets, compound targets/uterine fibroids targets and other human proteins.
| Pathway | Gene count | % | P-value | Fold enrichment | Benjamini |
|---|---|---|---|---|---|
| Phosphoinositide 3-kinase/Akt signaling | 73 | 0.142 | 1.30E-29 | 4.6 | 3.80E-28 |
| Ras signaling | 53 | 0.103 | 2.20E-23 | 5.1 | 3.30E-22 |
| Mitogen-activated protein kinase signaling | 45 | 0.087 | 7.20E-15 | 3.8 | 4.40E-14 |
| Estrogen signaling | 39 | 0.076 | 4.60E-26 | 8.5 | 9.90E-25 |
| ErbB signaling | 36 | 0.070 | 6.90E-25 | 9.0 | 1.40E-23 |
| Vascular endothelial growth factor signaling | 30 | 0.058 | 2.60E-23 | 10.7 | 3.70E-22 |
| Wingless-type signaling | 23 | 0.045 | 2.30E-7 | 3.6 | 7.20E-7 |
| Epidermal growth factor signaling | 20 | 0.039 | 1.70E-11 | 5.4 | 8.20E-10 |
| Insulin-like growth factor-1 signaling | 17 | 0.033 | 1.10E-10 | 5.9 | 3.90E-9 |
| Nuclear factor-κB signaling | 16 | 0.031 | 8.10E-6 | 4.0 | 2.20E-5 |
| Transforming growth factor-β signaling | 15 | 0.029 | 2.10E-5 | 3.9 | 5.40E-5 |
| Apoptosis | 14 | 0.027 | 3.50E-6 | 4.9 | 9.70E-6 |
| Mechanistic target of rapamycin signaling | 10 | 0.037 | 5.60E-3 | 2.8 | 2.30E-2 |
Benjamini score was derived from the DAVID database. Percentage values were calculated from the associated genes/total genes.