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. 2017 Sep 22;14(5):4910–4918. doi: 10.3892/etm.2017.5196

Figure 3.

Figure 3.

Activation of NF-κB p65 in the spinal dorsal horn on day 3 after MA in the Sham, CFA, DEX and EGCG groups. Immunohistochemistry revealed markedly decreased of NF-κB p65 in the DEX and EGCG groups on day 3 after MA. *P<0.01, CFA vs. SHAM; #P<0.01, CFA vs. DEX; £P<0.01, CFA vs. EGCG. Magnification, ×20. Sham, i.a. injection with 50 µl sterile saline and i.t. injection with 20 µl sterile saline for 3 consecutive days; CFA, i.a. injection with 50 µl CFA; DEX, i.a. injection with 50 µl CFA and i.t. injection with DEX (2.5 µg/20 µl) for 3 consecutive days; EGCG, i.a. injection with 50 µl CFA and i.t. injection with EGCG 30 µg for 3 consecutive days. i.t., intrathecal; i.a., intra-articular; NF, nuclear factor; CFA, complete Freund's adjuvant; MA, monoarthritis; DEX, dexmedetomidine; EGCG, epigallocatechin gallate.