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. 2017 Sep 18;14(5):5087–5092. doi: 10.3892/etm.2017.5121

Figure 1.

Figure 1.

Expression of miR-146b-5p is increased in human macrophages in clinical specimens and is induced by oxLDL. (A) Levels of miR-146b-5p in atherosclerotic lesions (n=10) and normal veins (n=10) from the same patients with AS. (B) Analysis of miR-146b-5p expression in THP-1 cells, which were first stimulated with PMA (100 nM) to induce them to differentiate into macrophages and then treated with oxLDL at the indicated doses (0, 10, 50 or 100 µg/ml). (C) miR-146b-5p expression in THP-1 cells, which were first stimulated with PMA (100 nM) to induce them to differentiate into macrophages and then treated with oxLDL (50 µg/ml) for the indicated times (0, 6 or 12 h). miR-146b-5p was determined by reverse-transcription quantitative polymerase chain reaction analysis. *P<0.05, **P<0.01, ***P<0.001 vs. control. miR, microRNA; oxLDL, oxidized low-density lipoprotein; PMA, phorbol 12-myristate 13-acetate.