Table IV.
Overlapping genes that were associated with the development and progression of multiple myeloma, and were putative target genes of microRNA-19a (n=41).
| Gene abbreviation | Gene name | Count | P-value |
|---|---|---|---|
| CCND1 | Cyclin D1 | 78 | <0.0001 |
| CCNA2 | Cyclin A2 | 1 | 0.2128 |
| CCND2 | Cyclin D2 | 16 | <0.0001 |
| CD69 | CD69 molecule | 1 | 0.0818 |
| CTGF | Connective tissue growth factor | 1 | 0.2861 |
| S1PR1 | Sphingosine-1-phosphate receptor 1 | 1 | 0.1044 |
| EREG | Epiregulin | 1 | 0.0388 |
| ESR1 | Estrogen receptor 1 | 3 | 0.4207 |
| F3 | Coagulation factor III (thromboplastin, tissue factor) | 2 | 0.0853 |
| GJA1 | Gap junction protein, α 1, 43kDa | 1 | 0.2950 |
| GRK6 | G protein-coupled receptor kinase 6 | 1 | 0.0625 |
| ID2 | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 1 | 0.1265 |
| IL6ST | Interleukin 6 signal transducer (gp130, oncostatin M receptor) | 2 | 0.0231 |
| ITGA6 | Integrin, α 6 | 1 | 0.1979 |
| KIT | V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 10 | <0.0001 |
| KRAS | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 1 | 0.5071 |
| LIF | leukemia inhibitory factor (cholinergic differentiation factor) | 1 | 0.1516 |
| SMAD4 | SMAD family member 4 | 1 | 0.3981 |
| MDM4 | Mdm4 p53 binding protein homolog (mouse) | 1 | 0.1155 |
| PTEN | Phosphatase and tensin homolog | 5 | 0.0038 |
| ATXN1 | Ataxin 1 | 1 | 0.1155 |
| SDC1 | Syndecan 1 | 46 | <0.0001 |
| TGFBR2 | Transforming growth factor, β receptor II (70/80kDa) | 1 | 0.3081 |
| THBS1 | Thrombospondin 1 | 1 | 0.3418 |
| KLF10 | Kruppel-like factor 10 | 1 | 0.0487 |
| TNFAIP3 | Tumor necrosis factor, α-induced protein 3 | 2 | 0.0064 |
| SOCS1 | Suppressor of cytokine signaling 1 | 8 | <0.0001 |
| SOCS3 | Suppressor of cytokine signaling 3 | 3 | 0.0022 |
| HDAC4 | Histone deacetylase 4 | 1 | 0.1463 |
| FOXP1 | Forkhead box P1 | 2 | 0.0016 |
| MIB1 | Mindbomb homolog 1 (Drosophila) | 1 | 0.0267 |
| PCDH10 | Protocadherin 10 | 1 | 0.0226 |
| CYLD | Cylindromatosis (turban tumor syndrome) | 1 | 0.1007 |
| PTK2B | PTK2B protein tyrosine kinase 2 β | 1 | 0.2757 |
| IGF1 | Insulin-like growth factor 1 (somatomedin C) | 14 | <0.0001 |
| MAPK10 | Mitogen-activated protein kinase 10 | 3 | 0.0001 |
| RAF1 | V-raf-1 murine leukemia viral oncogene homolog 1 | 1 | 0.4154 |
| SGK1 | Serum/glucocorticoid regulated kinase 1 | 2 | 0.0173 |
| TSC1 | Tuberous sclerosis 1 | 1 | 0.1861 |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 4 | 0.0002 |
| TLR2 | Toll-like receptor 2 | 1 | 0.5613 |