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. 2017 Sep 18;14(5):4831–4838. doi: 10.3892/etm.2017.5125

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Expression of CREB in hippocampus and prefrontal cortex tissues. At mRNA level, CREB expression was significantly decreased in depression group compared with depression group and all the four drugs significantly increased its expression (A and C). Western blot analysis showed that p-CREB/CREB was significantly decreased in depression group compared with control group, and only Radix Paeoniae Alba did not significantly increase p-CREB/CREB (B and D). **Compared with control group, P<0.01. ^#Compared with depression models, P<0.05. ^##Compared with depression models, P<0.01. CREB, cyclic AMP response element binding protein; p-, phosphorylated; 1, control group; 2, depression group; 3, Shuyu group; 4, fluoxetine group; 5, Radix Bupleuri; 6, Radix Paeoniae Alba.