Figure 8.
B-Z junction formation in the d(GAC)6·d(GAC)6 duplex facilitates the accommodation of hZαADAR1 in the minor groove. A, snapshots of d(GAC)6·d(GAC)6–hZαADAR1 complex MD simulation reveal that the β hairpins of the hZαADAR1 dimer interact with the duplex through its minor groove (A … A mismatches are colored red). B–D, time versus hydrogen bond distance profile corresponding to hZαADAR1 monomers A (B and C) and B (D). See text for details. E, snapshot illustrating all hydrogen bonding interactions between d(GAC)6·d(GAC)6 and hZαADAR1 during the simulation.