Table 3.

Evolution in ventilatory measurements

	Inclusion	Day 2	Day 3	Day4	Day 5	Difference	% change	p
PPLAT (cmH2O)	31.5 [28.8; 35.5]	25.0 [22.5; 30.5]	26.0 [22.0; 29.5]	25.0 [22.0; 27.0]	24.0 [21.0; 26.0]	10.0 [4.5; 12.5]	−31.4 [−36.2; −15.4]	0.008
VT (mL)	334 [317; 469]	300 [270; 353]	318 [270; 390]	300 [251; 344]	308 [243; 347]	69.0 [20.0; 90.0]	−20.9 [−26.3; −5.17]	0.008
VT/PBW (mL/kg)	6.85 [6.31; 7.48]	5.60 [4.90; 6.05]	5.80 [4.75; 6.45]	5.30 [4.55; 6.20]	5.00 [4.55; 5.95]	1.6 [0.8; 2.15]	−23.7 [−31.3; −13.9]	0.008
Driving Pressure: PPLAT –PEEP (cmH2O)	19.0 [17.5; 24.0]	14.0 [11.0; 18.5]	15.0 [11.0; 19.0]	15.0 [11.0; 17.0]	14.0 [10.0; 16.5]	9.0 [3.5; 12]	−39.1 [−52.2; −21.7]	0.012
PEEP (cmH2O)	12.0 [9.0; 12.75]	11.0 [8.5; 14.5]	11.0 [8.0; 13,5]	10.0 [8.0; 11.50]	10.0 [8.0; 10.0]	2.0 [−1.0; 2.0]	16.7 [−16.7; 16.7]	0.305
Respiratory Rate	32.0 [27.8; 33.0]	30.0 [27.5; 31.5]	30.0 [27.0; 31.5]	30.0 [27.0; 33.5]	30.0 [26.0; 33.5]	3.0 [−1.0; 6.0]	9.1 [−3.0; 20.0]	0.235
pH	7.21 [7.11; 7.23]	7.33 [7.29; 7.38]	7.38 [7.31; 7.42]	7.39 [7.34; 7.44]	7.43 [7.40; 7.44]	0.23 [0.20; 0.26]	3.19 [2.77; 3.63]	0.008
PaO2/FiO2 (mmHg)	83.0 [67.6; 105.4]	131.4 [90.2; 212.7]	137.2 [118.9; 223.8]	142.0 [116.1; 245.5]	233.6 [135.7; 320.1]	91.9 [29.9; 213.8]	144.0 [30.8; 232.2]	0.011
PaCO2 (mmHg)	68.3 [57.3; 86.2]	50.3 [42.9; 63.9]	51.5 [48.2; 62.2]	56.8 [46.6; 63.1]	59.3 [48.2; 60.9]	14.6 [4.0; 35.8]	22.2 [6.9; 38.0]	0.021
HCO3−	22.6 [22.1; 29.6]	25.7 [20.3; 34.1]	25.7 [25.3; 30.0]	29.1 [27.9; 39.3]	35.3 [29.4; 41.9]	−7.6 [−12.1; −3.2]	−34.2 [−51.2; −14.8]	0.021
FiO2	0.83 [0.68; 1.00]	0.55 [0.40; 0.75	0.55 [0.35; 0.73]	0.60 [0.35; 0.73]	0.50 [0.35; 0.73]	0.25 [0.05; 0.5]	45.5 [5.9; 50.0]	0.017

Data are expressed as median [IQ25; IQ75]. Difference: the median of the difference between the data at time of inclusion and at day 5