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. 2017 Nov 27;3:27. doi: 10.1186/s40748-017-0066-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Study design – please see text for details. * In the presence of an indwelling arterial catheter, or if there is an arterial blood gas drawn by arterial stick, oxygenation index (OI) values are preferred for making decisions regarding study drug therapy over oxygen saturation index (OSI) values