Table 4.
Summary of hematology data; mean (SD), N = 8
| Variable (reference range and units) a |
Day | Group 1 | Group 2 | Group 3 | Group 4 | P value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment | Time | ||||||||||
| Red blood cell count (5.8–7.8 106/μL) |
−17 | 6.23 | (1.14) | 5.85 | (0.38) | 5.75 | (0.37) | 5.84 | (0.28) | 0.3548 | <0.0001 |
| −11 | 5.66 | (0.34) | 5.77 | (0.19) | 5.75 | (0.27) | 5.87 | (0.23) | |||
| 21 | 5.85 | (0.49) | 5.63 | (0.46) | 5.71 | (0.48) | 5.84 | (0.46) | |||
| 55 | 6.21 | (0.59) | 5.99 | (0.36) | 6.05 | (0.42) | 6.36 | (0.38) | |||
| 89 | 6.38 | (0.51) | 6.22 | (0.47) | 6.27 | (0.26) | 6.37 | (0.48) | |||
| Hemoglobin (14.1–18.7 g/dL) |
−17 | 13.16 | (2.23) | 12.44 | (0.72) | 12.43 | (0.77) | 12.71 | (0.56) | 0.2896 | <0.0001 |
| −11 | 12.05 | (0.32) | 12.31 | (0.49) | 12.55 | (0.48) | 12.79 | (0.43) | |||
| 21 | 12.49 | (0.82) | 12.18 | (0.92) | 12.50 | (0.93) | 12.88 | (0.87) | |||
| 55 | 13.68 | (1.11) | 13.33 | (0.96) | 13.70 | (0.82) | 14.51 | (0.56) | |||
| 89 | 13.88 | (0.76) | 13.50 | (1.06) | 14.13 | (0.37) | 14.16 | (0.71) | |||
| Hematocrit (41.0–55.3%) |
−17 | 42.60 | (7.67) | 39.50 | (2.38) | 39.66 | (2.68) | 40.48 | (1.89) | 0.1645 | <0.0001 |
| −11 | 38.48 | (1.35) | 38.93 | (1.41) | 39.68 | (1.67) | 40.64 | (1.17) | |||
| 21 | 39.18 | (2.57) | 37.68 | (2.71) | 38.98 | (2.97) | 40.18 | (2.71) | |||
| 55 | 42.58 | (3.30) | 41.06 | (2.56) | 42.58 | (2.45) | 44.84 | (1.78) | |||
| 89 | 43.29 | (2.56) | 41.90 | (3.21) | 43.86 | (0.98) | 44.24 | (2.44) | |||
| Platelet count (161.6–379.0 103/μL) |
−17 | 297.13 | (75.13) | 268.00 | (106.63) | 384.75 | (61.17) | 318.63 | (64.39) | 0.9909 | <0.0001 |
| −11 | 320.75 | (63.09) | 287.75 | (54.84) | 366.38 | (50.36) | 296.75 | (71.34) | |||
| 21 | 323.50 | (57.94) | 317.88 | (63.30) | 352.75 | (42.68) | 309.00 | (93.97) | |||
| 55 | 300.13 | (43.28) | 275.00 | (47.67) | 326.75 | (34.01) | 287.75 | (56.39) | |||
| 89 | 275.88 | (36.74) | 257.50 | (31.27) | 308.00 | (31.60) | 267.38 | (66.42) | |||
| White blood cell count (7.4–14.5 103/μL) | −17 | 9.64 | (1.54) | 8.27 | (1.18) | 9.93 | (1.96) | 9.34 | (1.56) | 0.0433 | <0.0001 |
| −11 | 9.45 | (1.67) | 8.58 | (2.08) | 10.05 | (2.91) | 9.12 | (1.53) | |||
| 21 | 8.39 | (1.40) | 6.93 | (0.70) | 8.54 | (2.15) | 6.95 | (0.91) | |||
| 55 | 9.14 | (2.13) | 7.11 | (0.98) | 8.63 | (2.10) | 7.26 | (0.51) | |||
| 89 | 9.47 | (1.01) | 7.95 | (1.20) | 9.83 | (2.20) | 9.12 | (1.62) | |||
| Activated partial thromboplastin time (sec) b |
−17 | 11.35 | (0.67) | 11.56 | (0.83) | 11.63 | (0.71) | 11.44 | (0.75) | 0.8555 | 0.0859 |
| −11 | 13.68 | (1.36) | 13.60 | (1.71) | 13.05 | (1.20) | 13.55 | (0.95) | |||
| 21 | 12.74 | (0.78) | 12.24 | (1.01) | 12.24 | (0.35) | 12.49 | (1.22) | |||
| 55 | 12.26 | (1.05) | 12.98 | (2.25) | 12.61 | (2.20) | 11.80 | (1.30) | |||
| 89 | 12.13 | (0.91) | 12.21 | (1.85) | 11.76 | (0.57) | 11.91 | (0.67) | |||
a These reference ranges have been derived from healthy young mongrel dogs (n = 124) and have been provided by the animal supplier. They are to be used for information only and the two values collected before the dosing period (at Day −17 and −11) should be used for interpretation in the context of this study
b Not available in mongrel dogs