Table 5.
Summary of clinical chemistry data; mean (SD), N = 8
| Variable (reference range and units) a |
Day | Group 1 | Group 2 | Group 3 | Group 4 | P value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment | Time | ||||||||||
| Alanine aminotransferase (23.0–64.6 U/L) |
−17 | 20.88 | (7.12) | 21.88 | (4.91) | 18.75 | (4.65) | 21.75 | (5.01) | 0.7693 | <0.0001 |
| −11 | 21.75 | (4.23) | 22.00 | (3.78) | 21.00 | (3.82) | 24.38 | (7.11) | |||
| 21 | 25.50 | (6.00) | 26.50 | (4.28) | 24.13 | (4.36) | 26.88 | (5.36) | |||
| 55 | 28.50 | (6.44) | 29.25 | (4.95) | 27.63 | (5.21) | 29.50 | (6.09) | |||
| 89 | 32.00 | (7.84) | 31.13 | (4.67) | 29.50 | (4.14) | 31.13 | (5.84) | |||
| Aspartate aminotransferase (28.1–59.7 U/L) |
−17 | 29.00 | (5.04) | 30.25 | (4.06) | 28.25 | (4.27) | 30.63 | (2.97) | 0.5585 | 0.0002 |
| −11 | 30.88 | (3.68) | 30.63 | (3.46) | 29.88 | (2.85) | 32.25 | (4.46) | |||
| 21 | 28.50 | (3.74) | 29.75 | (2.60) | 29.63 | (3.74) | 30.25 | (4.62) | |||
| 55 | 28.75 | (3.24) | 31.38 | (4.50) | 30.38 | (6.23) | 32.00 | (5.50) | |||
| 89 | 31.50 | (5.86) | 33.00 | (4.07) | 32.88 | (3.44) | 34.38 | (5.04) | |||
| Alkaline phosphatase (65.4–177.5 U/L) |
−17 | 118.88 | (22.90) | 109.00 | (30.81) | 139.13 | (32.89) | 117.25 | (23.92) | 0.8396 | <0.0001 |
| −11 | 126.88 | (27.03) | 114.88 | (32.42) | 146.63 | (33.43) | 120.00 | (25.60) | |||
| 21 | 92.88 | (19.98) | 86.00 | (25.47) | 104.50 | (29.08) | 88.50 | (22.77) | |||
| 55 | 80.13 | (15.63) | 75.13 | (17.31) | 89.13 | (25.05) | 76.25 | (19.77) | |||
| 89 | 62.75 | (13.47) | 56.38 | (13.41) | 73.63 | (22.92) | 59.13 | (15.82) | |||
| Urea nitrogen (10.0–22.0 mg/dL) |
−17 | 10.25 | (2.25) | 10.75 | (1.28) | 9.75 | (1.49) | 10.38 | (1.60) | 0.0196 | 0.0823 |
| −11 | 12.00 | (1.93) | 11.50 | (1.69) | 11.00 | (1.31) | 12.38 | (2.07) | |||
| 21 | 16.00 | (1.77) | 15.50 | (1.07) | 13.13 | (2.10) | 14.50 | (2.20) | |||
| 55 | 16.00 | (2.56) | 17.13 | (1.96) | 14.75 | (2.25) | 14.88 | (2.10) | |||
| 89 | 16.63 | (2.62) | 16.38 | (2.39) | 14.25 | (2.25) | 14.63 | (1.69) | |||
| Creatinine (0.7–1.1 mg/dL) |
−17 | 0.61 | (0.06) | 0.56 | (0.05) | 0.60 | (0.08) | 0.60 | (0.05) | 0.9290 | <0.0001 |
| −11 | 0.60 | (0.08) | 0.59 | (0.04) | 0.59 | (0.06) | 0.59 | (0.06) | |||
| 21 | 0.79 | (0.06) | 0.78 | (0.05) | 0.78 | (0.07) | 0.81 | (0.04) | |||
| 55 | 0.95 | (0.09) | 0.94 | (0.07) | 0.90 | (0.09) | 0.93 | (0.09) | |||
| 89 | 1.00 | (0.05) | 1.00 | (0.09) | 0.99 | (0.08) | 0.98 | (0.07) | |||
| Total protein (5.3–6.4 g/dL) |
−17 | 4.75 | (0.15) | 4.71 | (0.14) | 4.84 | (0.32) | 4.91 | (0.20) | 0.4983 | <0.0001 |
| −11 | 4.71 | (0.15) | 4.74 | (0.18) | 4.85 | (0.24) | 4.80 | (0.14) | |||
| 21 | 4.98 | (0.07) | 4.99 | (0.16) | 5.09 | (0.28) | 5.11 | (0.15) | |||
| 55 | 5.23 | (0.13) | 5.24 | (0.09) | 5.35 | (0.19) | 5.36 | (0.23) | |||
| 89 | 5.10 | (0.15) | 5.25 | (0.16) | 5.36 | (0.20) | 5.24 | (0.32) | |||
| Albumin (2.9–3.9 g/dL) |
−17 | 3.26 | (0.15) | 3.23 | (0.10) | 3.29 | (0.19) | 3.36 | (0.18) | 0.9691 | 0.1652 |
| −11 | 3.25 | (0.14) | 3.20 | (0.09) | 3.30 | (0.19) | 3.29 | (0.12) | |||
| 21 | 3.50 | (0.09) | 3.44 | (0.13) | 3.55 | (0.12) | 3.54 | (0.15) | |||
| 55 | 3.51 | (0.15) | 3.51 | (0.19) | 3.48 | (0.16) | 3.55 | (0.15) | |||
| 89 | 3.53 | (0.10) | 3.54 | (0.13) | 3.64 | (0.14) | 3.53 | (0.20) | |||
| Creatine kinase (127.5–869.4 U/L) |
−17 | 365.38 | (57.30) | 359.38 | (80.96) | 342.75 | (22.22) | 417.88 | (96.99) | 0.6395 | 0.2253 |
| −11 | 318.38 | (50.07) | 322.88 | (57.31) | 324.75 | (38.87) | 403.50 | (91.48) | |||
| 21 | 240.88 | (46.46) | 289.75 | (66.14) | 277.88 | (60.09) | 336.25 | (170.44) | |||
| 55 | 223.25 | (60.46) | 248.13 | (57.50) | 254.00 | (48.67) | 302.38 | (96.44) | |||
| 89 | 270.00 | (148.55) | 255.50 | (65.44) | 314.38 | (134.62) | 285.88 | (52.55) | |||
a These reference ranges have been derived from healthy young mongrel dogs (n = 124) and have been provided by the animal supplier. They are to be used for information only and the two values collected before the dosing period (at Day −17 and −11) should be used for interpretation in the context of this study