TABLE 2.
Mixed-Level Logistic Regression Analysis of Average Ambient Air Pollutants and Cord Blood Immune System Biomarkers Among Boys, Odds Ratios, and 95% Confidence Intervals (n = 574)∗
| Pollutant† | IgE ≥0.5 ku/L | IL-33 ≥80%ile | TSLP ≥80%ile | IL-33/TSLP ≥80%ile |
| NO2, ppb | ||||
| ≤7.77 | 1.0 | 1.0 | 1.0 | 1.0 |
| 7.78 to ≤14.15 | 1.26 (0.61–2.62) | 0.80 (0.43–1.49) | 1.00 (0.54–1.84) | 0.91 (0.46–1.80) |
| 14.16 to ≤20.76 | 0.90 (0.41–1.99) | 0.80 (0.44–1.45) | 0.93 (0.51–1.69) | 0.86 (0.44–1.67) |
| >20.76 | 1.10 (0.50–2.43) | 0.90 (0.50–1.64) | 0.71 (0.38–1.34) | 0.95 (0.49–1.86) |
| 1 | 1.00 (0.96–1.04) | 1.01 (0.98–1.04) | 0.99 (0.96–1.02) | 1.01 (0.98–1.04) |
| PM2.5, μg/m3 | ||||
| ≤6.01 | 1.0 | 1.0 | 1.0 | 1.0 |
| 6.02 to ≤8.34 | 1.44 (0.74–2.79) | 0.86 (0.48–1.55) | 0.91 (0.51–1.63) | 0.90 (0.48–1.69) |
| 8.44 to ≤9.23 | 0.81 (0.36–1.80) | 1.58 (0.90–2.77) | 1.41 (0.80–2.48) | 1.53 (0.83–2.81) |
| >9.23 | 0.72 (0.33–1.60) | 1.32 (0.75–2.32) | 0.99 (0.55–1.76) | 0.94 (0.50–1.78) |
| 1 | 0.95 (0.81–1.10) | 1.09 (0.98–1.21) | 1.03 (0.92–1.14) | 1.02 (0.91–1.15) |
IgE, immunoglobulin E; IL, interleukin; TSLP, thymic stromal lymphopoietin.
*Adjusted for maternal age, household income (center and FSA are random effects).
†Pollutant concentrations are average exposure levels throughout pregnancy.