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. 2017 Nov 28;359:j5058. doi: 10.1136/bmj.j5058

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/.

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Fig 3 — Network plots of bleeding outcomes for review of prevention of stroke in patients with atrial fibrillation. Line thickness is proportional to the number of patients that contributed to the comparison *Doses of direct acting oral anticoagulants (DOACs) that were excluded from the primary analysis owing to not being considered to be of interest to inform health decisions in the UK (eg, warfarin interventions using subtherapeutic INR ranges), the total number of events was zero so they are uninformative, or they did not connect with the other trials in the network. †Excluded doses of DOACs that were included in sensitivity analyses. ‡Recommended doses of DOACs evaluated in a phase III trial; these are interventions of primary interest.