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Possible reasons for the success of REFLECT trial
| - Good trial design |
| Weight-based dosing (12 vs. 8 mg) |
| Noninferiority trial design |
| - Potent anticancer activity over sorafenib |
| - Acceptable toxicity |
| - Longer treatment duration due to better tolerability, especially less hand-foot-skin reaction (5.7 vs. 3.7 months) |
