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Effect of changes in pretreatment and post-treatment AFP level (A), platelet count (B), APRI (C), and FIB4 index (D) on HCC development in HPC patients without SVRs after IFN therapy (n = 552). AFP = alpha-fetoprotein, APRI = Aminotransferase-to-Platelet Ratio Index, FIB4 = Fibrosis 4, HCC = hepatocellular carcinoma, HPC = hepatitis C, IFN = interferon, SVRs = sustained virological responses.
