Table 3.
Genes Achieving Genome-Wide Significance (P<2.5×10−6) for Any Long Term Average Blood Pressure Phenotype in the Meta-Analysis.
| Gene | Chr | Start position (Build 36) |
Length (bp) | SNPs | Study | SBP | DBP | MAP | PP |
|---|---|---|---|---|---|---|---|---|---|
| TMEM180 | 10 | 104211159 | 15634 | 26 | AGEN | 8.56E-06 | 1.93E-06 | 2.98E-07 | 4.79E-02 |
| CHARGE | 1.22E-03 | 9.62E-03 | 3.48E-03 | 9.06E-02 | |||||
| Meta | 2.02E-07 | 3.49E-07 | 2.25E-08 | 2.79E-02 | |||||
| ACTR1A | 10 | 104228975 | 23528 | 28 | AGEN | 5.76E-06 | 1.91E-06 | 2.58E-07 | 3.81E-02 |
| CHARGE | 1.34E-03 | 8.94E-03 | 3.61E-03 | 2.11E-01 | |||||
| Meta | 1.52E-07 | 3.22E-07 | 2.03E-08 | 4.68E-02 | |||||
| SUFU | 10 | 104253708 | 115503 | 87 | AGEN | 3.04E-06 | 9.00E-07 | 9.87E-08 | 2.03E-02 |
| CHARGE | 2.99E-04 | 3.10E-03 | 7.24E-04 | 1.25E-02 | |||||
| Meta | 1.98E-08 | 5.77E-08 | 1.74E-09 | 2.35E-03 | |||||
| ARL3 | 10 | 104423473 | 40708 | 14 | AGEN | 3.06E-07 | 8.99E-07 | 2.19E-08 | 1.02E-02 |
| CHARGE | 1.65E-02 | 3.53E-02 | 2.43E-02 | 8.51E-02 | |||||
| Meta | 1.02E-07 | 5.80E-07 | 1.19E-08 | 6.99E-03 | |||||
| SFXN2 | 10 | 104464287 | 24650 | 23 | AGEN | 4.40E-07 | 1.29E-06 | 3.14E-08 | 8.40E-03 |
| CHARGE | 1.86E-03 | 2.05E-03 | 1.64E-03 | 6.76E-02 | |||||
| Meta | 1.79E-08 | 5.49E-08 | 1.27E-09 | 4.81E-03 | |||||
| WBP1L | 10 | 104525877 | 40135 | 23 | AGEN | 7.16E-08 | 1.11E-06 | 1.79E-08 | 1.16E-03 |
| CHARGE | 5.31E-04 | 5.25E-05 | 5.05E-05 | 3.95E-03 | |||||
| Meta | 9.50E-10 | 1.43E-09 | 2.60E-11 | 6.09E-05 | |||||
| CYP17A1 | 10 | 104580277 | 7004 | 13 | AGEN | 3.71E-06 | 1.11E-04 | 4.42E-06 | 1.00E-03 |
| CHARGE | 2.59E-05 | 1.89E-05 | 2.40E-05 | 6.46E-04 | |||||
| Meta | 2.31E-09 | 4.40E-08 | 2.54E-09 | 9.85E-06 | |||||
| C10orf32 | 10 | 104603956 | 10753 | 14 | AGEN | 2.26E-08 | 2.96E-06 | 4.93E-08 | 5.33E-04 |
| CHARGE | 2.85E-05 | 1.84E-06 | 3.45E-06 | 8.09E-04 | |||||
| Meta | 1.87E-11 | 1.47E-10 | 5.17E-12 | 6.75E-06 | |||||
| C10orf32-ASMT | 10 | 104603956 | 47690 | 37 | AGEN | 3.98E-08 | 5.22E-06 | 8.67E-08 | 3.32E-04 |
| CHARGE | 2.72E-06 | 3.27E-06 | 6.14E-06 | 5.18E-05 | |||||
| Meta | 3.34E-12 | 4.40E-10 | 1.56E-11 | 3.25E-07 | |||||
| AS3MT | 10 | 104619199 | 32447 | 37 | AGEN | 1.01E-07 | 4.90E-05 | 6.77E-07 | 2.57E-04 |
| CHARGE | 2.14E-06 | 3.39E-06 | 7.43E-06 | 4.08E-05 | |||||
| Meta | 6.52E-12 | 3.91E-09 | 1.36E-10 | 2.03E-07 | |||||
| CNNM2 | 10 | 104668064 | 160271 | 122 | AGEN | 3.94E-08 | 5.32E-06 | 1.50E-07 | 2.64E-04 |
| CHARGE | 1.33E-06 | 8.92E-06 | 3.15E-05 | 2.85E-05 | |||||
| Meta | 1.65E-12 | 1.18E-09 | 1.28E-10 | 1.48E-07 | |||||
| NT5C2 | 10 | 104837763 | 105291 | 77 | AGEN | 2.05E-08 | 1.08E-05 | 1.21E-07 | 1.94E-04 |
| CHARGE | 1.38E-06 | 1.66E-05 | 4.84E-05 | 2.83E-05 | |||||
| Meta | 9.11E-13 | 4.20E-09 | 1.57E-10 | 1.10E-07 | |||||
| NCR3LG1 | 11 | 17329884 | 25561 | 16 | AGEN | 5.27E-05 | 6.60E-03 | 1.93E-03 | 8.14E-06 |
| CHARGE | 7.61E-04 | 2.18E-01 | 1.67E-02 | 8.26E-04 | |||||
| Meta | 7.23E-07 | 1.09E-02 | 3.66E-04 | 1.33E-07 | |||||
| KCNJ11 | 11 | 17363371 | 3412 | 10 | AGEN | 8.55E-06 | 3.32E-03 | 5.65E-04 | 9.19E-07 |
| CHARGE | 1.62E-05 | 2.70E-02 | 3.75E-04 | 9.69E-05 | |||||
| Meta | 3.28E-09 | 9.25E-04 | 3.47E-06 | 2.15E-09 | |||||
| ATP2B1 | 12 | 88505956 | 68020 | 19 | AGEN | 2.03E-06 | 8.94E-07 | 5.92E-07 | 9.31E-03 |
| CHARGE | 8.40E-15 | 2.91E-13 | 5.19E-17 | 4.96E-07 | |||||
| Meta | <1.0E-17 | <1.0E-17 | <1.0E-17 | 9.32E-08 |
DBP=Diastolic blood pressure; MAP=Mean arterial pressure; PP=Pulse pressure; SBP=Systolic blood pressure
Note: Bolded are significant gene-based associations with discovery stage P<1.0×10−4, replication stage P<0.05, and joint meta-analysis P<5.0×10−6.