The cubic spline regression with 4 knots (referent 1.9) estimates the hazard ratio of serum aldosterone up to 99th percentile with incident CVD. Dotted lines represent 95% confidence intervals. Below each spline is the histogram of the distribution of serum aldosterone concentration. A) unadjusted B) fully adjusted (age, sex, education, current occupation status, smoking, physical activity, dietary intake, alcohol use and body mass index, systolic blood pressure, low-density lipoprotein, HbA1c and eGFR.