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. Author manuscript; available in PMC: 2017 Nov 28.
Published in final edited form as: Cancer Immunol Res. 2014 Mar 3;2(6):547–558. doi: 10.1158/2326-6066.CIR-13-0174

Figure 3. FLAMLKNTV is an immunogenic epitope of CT7 that induces IFN-γ production by T cells isolated from HLA-A*0201+ MM patients.

Figure 3

Intracellular IFN-γ production was measured in freshly isolated PBMC from 7 HLA-A*0201-expressing patients. Greater IFN-γ production by CD8+ T cells is observed in response to autologous PBMC pulsed with the HLA-A*0201-restricted immunogenic epitope FLAMLKNTV compared to non-pulsed control autologous PBMC targets. (A) UPN4 (B) UPN5 (C) UPN7 (D) UPN10 (E) UPN11 (F) UPN12 (G) UPN13. (H) FLAMLKNTV-induced IFN-γ production is significantly greater than the IFN-γ production to non-pulsed control targets (p = 0.0156, Wilcoxon matched pairs signed rank test).