Table 3.
Covariate (Covariate definition and categories described in Methods) | P for association of covariate with LR | Margin status (adjusted OR) | Threshold distance for negative margins (adjusted OR) | P for association [P for trend] for margin distance | ||||||
---|---|---|---|---|---|---|---|---|---|---|
No of studies | Unadjusted | Adjusted for margins & follow-up time | Negative | Positive/close | > 0 mm | 1mm | 2mm | 5mm | adjusted for covariate | |
Effect of margins (adjusted for follow-up time) | 33 | 1.0 | 1.96** | 1.47 | 1.0 | 0.95 | 0.65 | 0.12 [0.21] | ||
Age | 32 | 0.11 | 0.089 | 1.0 | 1.91** | 1.56 | 1.0 | 1.13 | 0.72 | 0.12 [0.29] |
Median-year of study recruitment | 33 | <0.0001 | 0.0086 | 1.0 | 1.96** | 1.47 | 1.0 | 0.95 | 0.65 | 0.26 [0.14] |
Proportion had endocrine therapy | 27 | <0.0001 | 0.0011 | 1.0 | 2.07** | 1.11 | 1.0 | 0.91 | 0.77 | 0.19 [0.32] |
Proportion ER-positive | 24 | 0.012 | 0.023 | 1.0 | 2.26** | 0.87 | 1.0 | 0.98 | 0.56 | 0.44 [0.25] |
Proportion had re-excision# | 17 | 0.032 | 0.088 | 1.0 | 2.06** | 1.41 | 1.0 | 0.82 | 0.52 | 0.22 [0.13] |
LR type (first vs any)§ | 33 | 0.12 | 0.058 | 1.0 | 1.96** | 1.11 | 1.0 | 0.83 | 0.51 | 0.063 [0.074] |
Indicates OR significantly different to referent at P<0.001
Odds of LR increased as proportion receiving re-excision increased
LT type (see ‘Definition of variables’ in Methods): odds of LR were lower for ‘first’ than ‘any’