TABLE 1.
Ratio of Cytoplasmic/Nuclear Survivin Levels
| Tumor | TP53 status |
Control | 2 Gy – 24 h |
5 mGy – 15 min −2 Gy – 24 h |
|---|---|---|---|---|
| HCT116 | WT | 1.01 | 0.96 | 3.20 |
| RKO | WT | 1.05 | 1.06 | 3.59 |
| MCF7 | WT | 1.85 | 0.87 | 4.67 |
| A549 | WT | 1.11 | 1.12 | 4.21 |
| Hs766T | WT | 1.34 | 1.20 | 4.20 |
| HCT116 | Isogenic null | 1.02 | 0.96 | 0.24 |
| RKO | Isogenic null | 1.06 | 0.95 | 0.32 |
| MDA-MB-231 | Mut | 1.62 | 1.54 | 0.63 |
| NCI-H1975 | Mut | 1.00 | 1.09 | 0.35 |
| Panc-1 | Mut | 1.71 | 1.89 | 0.54 |
| HCT116 | Mixed culturea | 1.25 | 0.96 | 0.36 |
| RKO | Mixed culturea | 1.05 | 1.39 | 0.30 |
a
75% TP53 WT cells/25% TP53 isogenic null cells.