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. Author manuscript; available in PMC: 2017 Nov 28.
Published in final edited form as: Antiviral Res. 2013 Sep 19;100(2):535–545. doi: 10.1016/j.antiviral.2013.09.010

Table 1.

Comparison of West Nile virus human neurological signs and symptomsa to those seen in mice and hamstersb (Adapted from (Morrey et al., 2004b)).

Human subject signs and symptoms Mouse signsb Hamster signs b References
Fever (influenza-like illness, biphasic, chill) ND fever with meningitis (Bode et al., 2006; Petersen and Marfin, 2002; Wang et al., 2013a; Weiss et al., 2001)
Meningitis, encephalitis meningoencephalitis meningoencephalitis (Ben-Nathan et al., 1996; Camenga et al., 1974; Hunsperger and Roehrig, 2006; Omalu et al., 2003; Sampson et al., 2000; Sejvar et al., 2003a; Steele et al., 2000; Weiss et al., 2001)
Headache ND ND (Asnis et al., 2000; Carson et al., 2006; Mazurek et al., 2005; Sejvar et al., 2003a)
Neck stiffness (nuchal rigidity) ND ND (Chapa et al., 2003)
Poliomyelitis, paralysis, paresis poliomyelitis poliomyelitis, paralysis, paresis (Doron et al., 2003; Fratkin et al., 2004; Hunsperger and Roehrig, 2006; Jeha et al., 2003; Omalu et al., 2003; Sejvar et al., 2005; Sejvar et al., 2003a; Sejvar et al., 2003b; Xiao et al., 2001)
Tremors, Parkinsonism tremors - rare tremors in extremities (Carson et al., 2006; Morrey et al., 2004b; Sejvar et al., 2003a; Wang et al., 2013b)
Memory impairment ND spatial memory deficit (Carson et al., 2006; Cook et al., 2010; Gottfried et al., 2005; Jeha et al., 2003; Lindsey et al., 2010; Mazurek et al., 2005; Smeraski et al., 2011)
Conjunctivitis, chorioretinitis ND, no ocular exudate ND, ocular exudate (Asnis et al., 2000; Khairallah et al., 2004)
Respiratory distress ND lethal respiratory distress (Agamanolis et al., 2003; Betensley et al., 2004; Morrey et al., 2012; Saad et al., 2005; Wang et al., 2013b)
Death (<0.1%) death (80-100%) death (60-90%) (Lindsey et al., 2010; Morrey et al., 2004b; Xiao et al., 2001) (Morrey et al., 2012; Oliphant et al., 2005)
Autonomic dysfunction not apparent non-lethal autonomic dysfunction (Fratkin et al., 2004; Leis and Stokic, 2005; Wang et al., 2011, 2013a)
Gastrointestinal distress ND duodenal EMG suppression (Mazurek et al., 2005; Wang et al., 2011; Weiss et al., 2001)
Cardiac arrhythmia (Bode et al., 2006; Wang et al., 2011)
Bladder dysfunction, urinary retention ND ND (Saad et al., 2005; Shpall et al., 2003; Wang et al., 2011)
Proprioception ND ND (Moon et al., 2005)
Confusion (altered mental status) ND ND (Jeha et al., 2003; Mazurek et al., 2005)
Coma ND ND (Sejvar et al., 2003a)
Backpain, myalagia, arthralgia ND ND (Jeha et al., 2003; Lindsey et al., 2010; Mazurek et al., 2005)
a

Not all subjects show all symptoms or signs.

b

Alignment with human symptoms were subjective and may not correlate exactly.

c

ND-Not determined